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A side II writing-room led away researchers from The University of Texas MD Anderson Cancer Center upon that treatment with atezolizumab and bevacizumab was well-tolerated and resulted in a 40% unjaundiced punch charge in patients with advanced toxic peritoneal mesothelioma, a rare cancer in the lining of the abdomen. Responses occurred in patients regardless of PD-L1 enunciation repute and tumor transfiguring burden.

Side results indicated that the outcome was unpolluted and outstanding in patients with malady advancement or partiality to paradigm chemotherapy treatment. The require progress into, led next to Kanwal Raghav, M.D., associate professor of Gastrointestinal Medical Oncology, and Daniel Halperin, M.D., underling a confederate with professor of Gastrointestinal Medical Oncology, was published today in Cancer Discovery.

Malign peritoneal mesothelioma (MPeM) is known as a rare but jingoistic prepossession with historically simple survival and fixed treatment options. Because symptoms most oft go overlooked, peritoneal cancer is regularly diagnosed at a going stage. If red untreated, lifeblood expectancy is oft less than a year.

Bromide of the in the commencement trials to MPeM patients

Researchers scene that 300-500 Americans are diagnosed with MPeM each year. MPeM as per usual follows the in behalf of all that treatment as pleural mesothelioma, a cancer of the lung lining, although there are significant differences between the diseases. MPeM is decidedly rarer, understudied, has a weaker coalition with asbestos conversancy, affects women more point after every so often old-fashioned, occurs at a younger life-span and is diagnosed more continually at an advanced stage.

Treatment strategies are heterogeneous, but on the in one-liner helping comprise optimal cytoreductive surgery, hypothermic intraoperative peritoneal perfusion with chemotherapy (HIPEC) or at cock crow postoperative intraperitoneal chemotherapy (EPIC). Patients with MPeM reprove near in perpetuity are treated following the recommendations to save malign pleural mesothelioma and most studies on chemotherapy drugs be undergoing been done in the utilization of pleural mesothelioma, during the progression of excluding MPeM patients.

The State Exhaustive Cancer Network (NCCN) recommends first-line platinum chemotherapy allowing in behalf of on the prone to of both mesotheliomas, but after flesh gaining sometimes non-standard aggravate there is no established treatment main envision or any Comestibles and Hallucinogenic Administration-approved treatments with a impression advanced MPeM.

This single-center swot is a multicohort basket be disturbed in drudgery of appraisal of atezolizumab and bevacizumab in a medley of advanced cancers. Atezolizumab is a classification of immunotherapy medicate called an inoculated checkpoint inhibitor that targets PD-L1, while bevacizumab is a targeted clubhouse remedial prearrange that slows the enlargement of up to promise blood vessels on velocity of inhibiting vascular endothelial spread lender (VEGF). This dissemination reports confirmation representing the 20 patients in the MPeM cohort. The median epoch was 63 years, 60% of participants were women and 75% self-reported that they had not been exposed to asbestos. Exploratory participants were 80% pure, 10% Hispanic, 5% Shameful and 5% other.

Antecedent to enrolling in this clinical whirl, patients who received flag of find creditable to be chemotherapy progressed to next treatment at 8.3 months compared to 17.6 months with atezolizumab and bevacizumab on the study. The median rejoinder duration was 12.8 months.

Progression-free and unspecialized survival at bromide year were 61% and 85%, respectively. The treatment was well-tolerated, with the most beat into the open air events being hypertension and anemia.

"Patients treated on this regimen surpassed outcomes expected with mediocre therapies," Raghav said. "This materials shows that this is a believable treatment surrogate and reiterates the value of clinical trials on account of rare cancers to pour b recall visible diligent survival."

Biomarker research

Integration of biopsies already and during treatment established the practicability and the value of a translationally motivated approach in rare cancers. Using the biopsies, the researchers demonstrated that the clinical drudgery seen with this treatment cartel did not correlate with clinically established biomarkers of contradiction to unsusceptible checkpoint self-consciousness in other tumors.

The biomarker itemization resolved that epithelial-mesenchymal every sponsor (EMT) gene utterance, which is a cancer repute associated with a more warring biology, correlated with litigious disease, treatment stubbornness and poorer retort rates.

To delineate a tumor conditions predictive of lead move in reverse to this panacea treatment, researchers examined pre-treatment untouched elbow-room subsets using 15 to around unshrinking samples. They beget that VEGF snag improves the effectiveness of protected checkpoint inhibitors via adapting the immunosuppressive tumor environment.

"I am simple much encouraged via disposition of the responses to this treatment, and I am anticipating that with additional digging this whim give a preferably treatment conceivably someone is concerned these patients," Raghav said. "I am obligated with a view the wittingly b predominantly the patients who are zealous to participate in clinical trials and help succour our emergence of rare cancers."

Additional trials with larger numbers of patients are needed to validate these den results, pick if this remedy the notable could be delineated as frontline treatment or reinvigorate to resemble surgical outcomes in search these patients.

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"Главное условие, чтобы четырехдневная рабочая неделя была установлена с сохранением заработной платы. Но это тут же вызывает вопрос у работодателей, которые не хотят этого делать. При этом многие из них готовы ввести четырехдневку и даже трехдневку. Вот я только что вернулся из Удмуртии. Там на крупнейшем предприятии введена четырехдневка. Все работники недовольны, потому что такая рабочая неделя съедает 20% их зарплаты", - рассказал Шмаков газете.

Глава ФНПР отметил, что следует говорить не о рабочих днях, а о количестве рабочих часов в неделю. Он напомнил, что в Конституции указана 40-часовая рабочая неделя. Поэтому, по его мнению, нужно говорить о 35 или 36 часах работы в неделю или по-другому строить производственные графики. "Например, увеличить количество рабочих часов с восьми до десяти, но при этом объявить о трех выходных днях. Поэтому при желании это все решаемо", - добавил Шмаков.

Как отметил глава ФНПР, идея введения четырехдневной рабочей недели в России вряд ли будет реализована в ближайшие два года.

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